One of the most important lessons I have learned from web publishing and development is that testing & optimization is absolutely critical. Often a few minor adjustments done in 30 minutes can bring in more revenue than months of work. Its even better when those adjustments are done on the fly, leaving you time to do thing machines can not.

Last month one of my readers contacted me about a new service he co-founded, Pubmatic.com. This service allows publishers to auto-optimize their ad inventory on the fly. Unlike Right Media’s RMX Direct, the built in support for Adsense & Yahoo should be a big benefit self-employed content publishers.

Pubmatic currently supports Adsense, Valueclick, BlueLithium, and YPN. Expanding supported ad networks is a top priority, and many more are expected. Text ad color schemes are auto-optimized. Planned additions to later versions include ad size optimization, page position, and number of ad units per page.

One of the case studies Pubmatic lists is Sportsvite.com, which saw its revenue jump 90% during Pubmatic’s alpha testing period. While other publishers may not see such dramatic successes, double digit revenue gains are considered normal.

If that didn’t impress you, then at least check out their desktop widget for Adsense, YPN, Valueclick, and Komli stats, Pubmatic account not required.

If you do want to test out Pubmatic, they are now in open beta, timed just for TechCrunch40.